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Drug Discovery

Novel Neuraminidase Inhibitor Shows Promise against H5N1 Avian Influenza Virus

Drug developers have shown that the novel antiviral neuraminidase inhibitor R-125489 administered as its prodrug CS-8958 works effectively against the highly pathogenic influenza A virus H5N1, including oseltamivir-resistant strains. More...
11 Mar 2010

Blocking Development of New Blood Vessels Augments Radiotherapy for Brain Tumors

High doses of radiotherapy fail to destroy glisoblatoma multiforme brain tumors, but radiation therapy at lower doses has proven to cure the disease in an animal model when used in combination with treatment to prevent formation of new tumor blood vessels. More...
11 Mar 2010

Scorpion Venom Could Serve as an Alternative to Morphine

Scorpion venom, a notorious poison, might be used as an alternative to dangerous and addictive painkillers such as morphine, according to a new study. More...
10 Mar 2010
Image: The Israeli desert scorpion Leiurus quinquestriatus (photo courtesy Wikipedia).

New Computational Tool Designed for Cancer Treatment

Many human tumors express indoleamine 2,3-dioxygenase, an enzyme that mediates an immune-escape in several cancer types. More...
05 Mar 2010

Sceptrin Restricts Cell Motility and May Prevent Tumor Metastasis

Investigators have demonstrated the ability of the natural compound sceptrin to inhibit the motility of cells and suggested a possible future role for this compound as a drug to prevent the metastasis of tumor cells. More...
03 Mar 2010

Gold Nanoparticles Kill Cancer Cells by Stopping Cell Division

Gold nanoparticles that penetrate the nucleus of cancer cells damage the DNA, prevent the cells from completing the process of cell division, and lead to programmed death of the cells. More...
03 Mar 2010

Prototype Drug Blocks Critical Tuberculosis Virulence Factor

A chemical compound has been identified that inhibits the activity of the Mycobacterium tuberculosis protein, tyrosine phosphatase mPTPB, and may be the prototype for a new generation of drugs for the treatment of tuberculosis. More...
02 Mar 2010
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